75
23
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T34532 |
Sari 59-801
Sari-59-801 |
Others | Others |
Sari 59-801 是具有口服活性的降血糖化合物,能够降低几个物种的血糖,且可以提高大鼠和小鼠的血浆中胰岛素水平。 | |||
T10492 |
BD-AcAc 2
Ketone Ester |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
BD-AcAc 2 (Ketone Ester) 是一种酮单酯,是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆 乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。 | |||
T0214 |
Pioglitazone
U 72107,吡格列酮,匹格列酮 |
Ferroptosis; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Pioglitazone (U 72107) 是一种胰岛素增敏剂和噻唑烷二酮,适用于治疗 2 型糖尿病。它是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域,作用于人和鼠 PPARγ的EC50分别为 0.93 和 0.99 μM。 | |||
T30142 |
ARRY-403
AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151 |
Glucokinase | Metabolism |
ARRY-403 是一种新型葡萄糖激酶激活剂,可降低 2 型糖尿病患者的空腹和餐后血糖,可用于治疗糖尿病。 | |||
T22708 |
Darglitazone
CP-86325 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Darglitazone (CP-86325) 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。 | |||
T67728 |
α-Glucosidase-IN-23
|
Glucosidase | Metabolism |
α-Glucosidase-IN-23 是具有口服活性的 α-Glucosidase 抑制剂。α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖 (IC50= 4.48 μM)。α-Glucosidase-IN-23 可用于糖尿病的研究。 | |||
T14212 |
AMG-1694
|
Glucokinase | Metabolism |
AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白(GK-GKRP)干扰物,能促进 GK-GKRP 复合物的解离,其 IC50 值为 7 nM,从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常,并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GKRP 对 GK 活性的抑制作用,并促进 GK 转位。 | |||
T1782L |
Canagliflozin hemihydrate
JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 |
SGLT | GPCR/G Protein |
Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂,作用于表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞,IC50 分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T16083 |
Mizagliflozin
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT | GPCR/G Protein |
Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂,对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物,可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。 | |||
T63166 |
LSN3318839
LSN-3318839,LSN 3318839 |
Glucagon Receptor | GPCR/G Protein |
LSN3318839 是一种有效且可口服的胰高血糖素样肽-1受体(GLP-1R)变构调节剂。LSN3318839可增强GLP-1R的G蛋白偶联信号传导,可用来降低血糖。 | |||
T8818 |
TC-G 1005
(4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮 |
GPCR19 | GPCR/G Protein |
TC-G 1005 是具有口服活性的TGR5选择性激动剂,能够激活 hTGR5 (EC50:0.72 nM)和 mTGR5 (EC50:6.2 nM)。它能够减少小鼠体内葡萄糖水平。 | |||
T77781 |
Lotiglipron
PF-07081532 |
Glucagon Receptor | GPCR/G Protein |
Lotiglipron (PF-07081532) 是一种具有口服活性和有效性的 GLP-1R 激动剂,能够降低血糖和体重,可用于研究 2 型糖尿病 (T2DM) 和过度肥胖。 | |||
T6646 |
Rosiglitazone hydrochloride
盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物,通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。 | |||
T8221 |
Insulin (human)
INSULIN,甘精胰岛素,胰岛素,Insulin(human) |
IGF-1R | Tyrosine Kinase/Adaptors |
Insulin (human) 是一种多肽激素,可以促进糖原的合成,调节血液中的葡萄糖水平。Insulin (human) 具有降血糖活性,临床上用于治疗糖尿病患者的高血糖。 | |||
T6587 |
Mitiglinide Calcium
KAD-1229,米格列奈钙,S21403,米格列奈 |
ATPase; Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide Calcium (KAD-1229) 是一种 ATP 敏感的 K+通道拮抗剂,具有促胰岛素的作用。Mitiglinide Calcium 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide Calcium 在 2 型糖尿病的研究中具有价值。 | |||
T8526 |
Metformin
甲福明,二甲双胍,1,1-Dimethylbiguanide |
Mitophagy; AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂,具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制,常用于 2 型糖尿病的研究。 | |||
T40542 |
Sinbaglustat
ACT-519276,Sinbaglustat,OGT2378 |
Transferase | Metabolism |
Sinbaglustat (OGT2378) (OGT2378) 是葡萄糖神经酰胺合成酶 (GCS) 和非溶酶体葡萄糖神经酰胺酶 (GBA2) 的双重抑制剂。Sinbaglustat 是一种可透过血脑屏障的的口服N-烷基亚氨基糖。Sinbaglustat 可用于治疗溶酶体贮积症和研究溶酶体功能障碍相关的中枢神经退行性疾病。 | |||
T1530 |
Mitiglinide calcium hydrate
KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) 是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂, 属于促胰岛素化合物。它对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性,在 2 型糖尿病中有研究价值。 | |||
T20690 | Diacetoneglucose | ||
Diacetoneglucose, an Important glucose protective derivative, is used in the determination of blood glucose. | |||
T29154 |
WB403
WB-403,WB 403 |
||
WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α- | |||
T24261 |
KHG26693
KHG-26693,KHG 26693 |
||
KHG26693 is an anti-inflammatory and antioxidant agent that acts by significantly decreasing blood glucose, triglycerides, cholesterol and increased insulin. | |||
T10506 |
PPAR agonist 1
|
PPAR | DNA Damage/DNA Repair; Metabolism |
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol. | |||
T27418 |
Glybuzole
Desaglybuzole,Sulfamidothiodiazol,Gludiase,Glybuzolum |
||
Glybuzole is a sulfonamide derivative, it is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells. | |||
T68472 | Adomeglivant, (+)- | ||
Adomeglivant, (+)-, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. | |||
T26661 | AS1708727 | ||
AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level. | |||
T26617 |
AMG-221
AMG221 |
||
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice. | |||
T31838 |
Folic acid, methyl-
x-Methylfolic acid,x-Methyl folic acid,x-Methylpteroylglutamic acid |
||
Folic acid, methyl- is a nutrient that belongs to the vitamin B family. Folate is significant for the easy conversion of carbohydrates into glucose and is essential in red blood cell formation, cell division, detoxification, and the production of some neu | |||
T28897 |
T-1095A
T 1095A,J1.265.331J |
||
T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and haemoglobin A(1C) levels, and improved | |||
T27228 |
E-3030 free acid
E-3030,E3030,E 3030 |
||
E-3030 free acid is a peroxisome proliferator-activated receptor (PPAR) agonist. E-3030 decreased blood glucose, triglyceride, non-esterified fatty acids, and insulin levels and increased blood adiponectin levels. Triglyceride- and non-high-density lipopr | |||
T68922 |
YM543 free base
|
||
YM543 free base 为口服有效的钠-葡萄糖协同转运蛋白(SGLT) 2抑制剂,主要用于降低血糖水平,适用于糖尿病研究。 | |||
T68098 |
Midaglizole
(±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base |
||
Midaglizole ((±)-DG5128 free base, DG5128 free base) 是一种有效的α2-adrenoceptor 拮抗剂。Midaglizole 是一种降血糖药。Midaglizole 在具有升高血压并降低血糖水平的作用。 | |||
T26724 |
AZD-9164 bromide
AZD9164,AZD-9164,AZD 9164 |
||
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels | |||
T60312 | FBPase-IN-1 | ||
FBPase-IN-1 is a powerful inhibitor of Fructose-1,6-bisphosphatase (FBPase), a key enzyme involved in Type 2 diabetes (T2D) research. It exhibits an impressive IC50 value of 0.22 μM. Aside from its potency, FBPase-IN-1 also demonstrates the ability to effectively lower blood glucose levels and improve glucose tolerance. Its mechanism of action involves covalently modifying the C128 site, thereby influencing the N125-S124-S123 allosteric pathway of FBPase, ultimately impacting its catalytic activ... | |||
T62542 |
GPR40 agonist 5
|
||
GPR40 agonist 5 是一种口服具有活力的 GPR40 (G 蛋白偶联受体 40) 激动剂 (EC50: 47 nM)。GPR40 agonist 5 能够减少血糖水平,改善糖耐量。GPR40 agonist 5 对 2 型糖尿病小鼠的高血糖状态表现出充足的控制作用。 | |||
T78794 |
α-Glucosidase-IN-31
|
Glucosidase | Metabolism |
α-Glucosidase-IN-31(compound R1)是一种有效的口服α-Glucosidase抑制剂,具有10.1 μM的IC50值,能显著降低血糖并具抗糖尿病活性。 | |||
T61166 | α-Glucosidase-IN-16 | ||
α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1]. | |||
T70390 |
YM-543 choline
|
||
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose level... | |||
T72143 |
Velagliflozin proline hydrate
|
||
Velagliflozin proline hydrate 是 Velagliflozin 的临床形式。Velagliflozin 是一种可口服的钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂,具有抗糖尿病的活性。 特别是,Velagliflozin 减少肾葡萄糖重吸收,促进葡萄糖尿,从而降低血糖和胰岛素浓度。 | |||
T79644 |
Antidiabetic agent 2
|
Glucosidase | Metabolism |
Antidiabetic agent 2 (Compound 56) 作为一种葡萄糖摄取促进剂,能有效地抑制DPP-4, PTP-1B, α-淀粉酶和α-葡萄糖苷酶,其IC50s分别达到0.036、0.042、0.241、0.185 μM,表现出显著的降血糖作用。 | |||
T70509 |
INU-101
|
||
INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefore shows promise as a potential treatment for type 2 diabetes and metabolic syndrome. | |||
T35798 |
Massarigenin C
|
||
Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidase (IC50= 1.25 mM).1It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg. | |||
T71809 |
L-Xylulose
|
||
L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs. | |||
T68471 |
(+/-)- Adomeglivant
|
||
(+/-)- Adomeglivant, also known as LY2409021, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Blockade of glucagon signalling in patients with type 2 diabetes is well tolerated and results in substantial reduction of fasting and postprandial glucose with minimal hypoglycaemia, but with reversible increases in aminotransferases. Inhibition of glucagon signalling by LY2409021 is a promising potential treatm... | |||
T60674 | DK1 | ||
DK1 是有效的雌激素相关受体调节剂。DK1 影响 ERRα 受体的活性,具有降低血糖的能力。DK1 显示出研究糖尿病的潜力。 | |||
T80305 |
A8SGLP-1
|
||
A8SGLP-1,一种口服活性GLP-1类似物,特点是其8位丙氨酸被丝氨酸替换。在不干扰功能的前提下,A8SGLP-1能有效降低db/db小鼠的血糖水平。 | |||
T81935 |
L-Glutamic γ-monohydroxamate
|
||
L-Glutamic γ-monohydroxamate是一种特异性抗肿瘤试剂,能够抑制癌细胞的增殖,并针对性地阻止微血管内皮细胞摄取L-组氨酸。作为钒配体,该化合物还能激活脂肪细胞对葡萄糖的摄取和代谢,进而有效降低血糖水平。 | |||
T80306 |
A8SGLP-1 TFA
|
||
A8SGLP-1 TFA为口服活性GLP-1类似物,8位丙氨酸被丝氨酸替代。在不干扰功能的前提下,可降低db/db小鼠血糖水平。 | |||
T72909 |
D-(+)-Sorbose
|
||
D-(+)-Sorbose,一种 D-Sorbose 的活性对映异构体,可抑制双糖酶活性并对大鼠餐后血糖和胰岛素水平有抑制作用。D-Sorbose 作为甜味剂有助于预防相关疾病,如 2 型糖尿病。 | |||
T81120 | SP4f | PPAR | DNA Damage/DNA Repair; Metabolism |
SP4f为PPAR-γ激活剂,其在HK-2细胞中EC50值为826 nM。在瑞士白化病小鼠中,SP4f能够降低血糖和脂质过氧化水平,同时提升谷胱甘肽含量和过氧化氢酶活性。 | |||
T36720 |
Deacetylforskolin
|
||
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucose transport in rat adipocyte plasma membranes.2Deactylforskolin (30-1,000 μg/kg) reduces blood pressure in spontaneously hypertensive rats.3It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4 1.Gabetta, B., Zini, G., and Danieli, B.Minor... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3675 |
1-Deoxynojirimycin
Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin |
PI3K; Glucosidase | Metabolism; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖,预防糖尿病。 | |||
T21344 |
1-Deoxynojirimycin hydrochloride
Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin |
PI3K; Antibacterial; Antibiotic; Glucosidase | Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂,具有降血糖、减肥和抗病毒的作用,可抑制餐后血糖,预防糖尿病。 | |||
T5S0669 |
Bergamottin
5-Geranoxypsoralen,Bergamotine,Bergaptin,佛手柑素 |
P450 | Metabolism |
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。 | |||
T4396 |
Officinalisinin I
|
Others | Others |
Officinalisinin I 是一种甾体皂苷,分离自 Anemarrhena asphodeloides。 | |||
T4726 |
D-Glucose 6-phosphate sodium
G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。 | |||
T5735 |
Methyl deacetylasperulosidate
Deacetyl asperulosidic acid methyl ester,6α-Hydroxygeniposide,去乙酰车叶草苷酸甲酯 |
Others | Others |
Methyl deacetylasperulosidate (6α-Hydroxygeniposide) 是环烯醚萜类化合物,能够降低正常小鼠的血糖水平,对小鼠具有通便作用。 | |||
T3332 |
Isosteviol
异甜菊醇,(-)-Isosteviol |
IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂,属于四环二萜糖苷,是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶,具有抗菌、抗癌和抗结核作用。 | |||
T5S0384 |
Rhapontin
Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside |
Apoptosis; Others | Apoptosis; Others |
Rhapontin (Ponticin) 是药用大黄的一种成分,可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性,改善血糖和血脂,表明其具有显着的降糖作用,有望成为治疗2型糖尿病及其并发症的新药。 | |||
T13979 |
(S)-3-Hydroxybutanoic acid
L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物,在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成,当血糖低时能够被脑用作能量来源。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T5069 |
D-Glucose 6-phosphate potassium salt
|
Others | Others |
在细胞中,当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中通过磷酸葡萄糖变位酶转化葡萄糖 1-磷酸时,会产生D-glucose 6-phosphate (G6P)。 G6P 位于糖酵解和戊糖磷酸途径的起点。当血糖水平高时,它也可以作为糖原储存。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T4825 |
D-(+)-Xylose
D(+)-Xylose,木糖,(+)-Xylose,Wood sugar |
Endogenous Metabolite | Metabolism |
D-(+)-Xylose (Wood sugar) 是一种是一种戊醛糖,其化学式为C5H10O5,甜度为蔗糖的40%。木糖也存在于结缔组织的粘多糖中,有时也存在于尿液中。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
TN1703 |
Glycyrin
|
HCV Protease; PPAR; Antifection | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice. | |||
T10020 |
1-Methyluric acid
1-Methyl-2,6,8-trihydroxypurine,1-Methylurate |
Endogenous Metabolite | Metabolism |
1-Methyluric acid (1-Methylurate) 作用于膀胱粘膜并增加胰岛素、甘油三酯、胆固醇和血糖的水平。 | |||
T73074 | Phanginin A | ||
Phanginin A 是有效的口服活性SIK1激活剂,通过抑制糖异生、增加p-SIK1表达及降低p-CREB表达,达到降低血糖水平、改善葡萄糖耐量和血脂异常的效果,显示出其在2型糖尿病研究中的潜力。 | |||
TMA0127 | Ficusin A | transporter; PPAR | DNA Damage/DNA Repair; Metabolism |
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPARγ expression and improve the transl | |||
T81222 |
Salvifaricin
|
||
Salvifaricin是一种口服活性的二萜类化合物,可从墨西哥鼠尾草和西班牙鼠尾草中提取。Salvifaricin能显著降低空腹血糖以及血清甘油三酯(TG)水平,表现出抗糖尿病的效果。 | |||
TN3779 | De-O-methyllasiodiplodin | IL Receptor; TNF; ROS; Antifection | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in d | |||
T80007 |
Stevisalioside A
|
Phosphatase | Metabolism |
Stevisalioside A (Compound 2),一种从甜叶菊根提取的化合物,展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B,IC50为526.8 μM,并能降低Stevisalioside A引起的高血糖小鼠血糖水平,改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。 | |||
TN4997 |
Serpentine
|
IGF-1R | Tyrosine Kinase/Adaptors |
Serpentine 是一种玫瑰花根中的生物碱,可用作胰岛素增敏剂,以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化,从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达,从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素(HFD/STZ)诱导的糖尿病小鼠中,Serpentine 显著延长了胰岛素的降血糖时间,显著降低了外源性胰岛素的使用,抑制了内源性胰岛素的分泌。 |